Research Day Agenda

Student & Faculty Research Poster Presentations

Thursday, April 6, 2017
1 to 3 p.m.
Athletic/Recreation Center Gym

30th Annual John C. Krantz, Jr., Distinguished Lecture

“Advancing Precision Medicine with the Science of Drug Transporters”

Thursday, April 6, 2017
4 to 5 p.m.
McNeil Science and Technology Center, AstraZeneca Auditorium
Reception to follow

presented by

Kim L.R. Brouwer, PharmD, PhD
Associate Dean for Research and Graduate Education
William R. Kenan, Jr., Distinguished Professor
UNC Eshelman School of Pharmacy
The University of North Carolina at Chapel Hill

Krantz Lecture Synopsis: The 21st century approach to developing the most effective treatment strategies for individual patients is advancing rapidly. In order to achieve the promise of precision medicine, health care providers must understand disease-specific and unique patient characteristics that influence drug disposition, response, and safety, and utilize this information to select optimal drug and dosage regimens. Recent advances in the science of drug transporters have revealed that these proteins play key roles in the absorption, distribution, and excretion of many medications, and contribute to patient variability in drug response. Patient-specific disease and genetic factors may alter the expression and function of drug transporters, thereby impacting drug efficacy and/or safety. Drug transporters may be the site of clinically important drug interactions or adverse drug reactions such as hepatotoxicity. Innovative in vitro and in vivo tools to assess transporter function, and mathematical modeling and simulation, facilitate the development of individualized dosing recommendations to achieve maximal therapeutic benefit in individual patients. In addition, systems pharmacology models integrating physiology and experimental data can evaluate transporter-mediated toxicity mechanisms, and identify risk factors for adverse events in humans. These cutting-edge advances in clinical pharmacology and drug transporter science will enable more precise tailoring of medicines for optimal treatment of every patient, the ultimate goal of precision medicine.


Jean-Francois Jasmin


University of the Sciences
600 South 43rd Street
Philadelphia, PA 19104-4495