Anil P. D'mello, PhD
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Anil D'mello, Ph.D.
BS, MS (Bombay); PhD (Pittsburgh)
Professor of Pharmaceutical Sciences
Director of BS Program in Pharmaceutical Sciences
Email: a.dmello@usp.edu
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Research Interests
Recent epidemiological studies have shown associations between low birth weight and increased susceptibility to chronic disease during adulthood. The authors hypothesize that prenatal insults program a set of cellular changes in the developing fetus which produce low birth weight, and predispose the offspring to chronic disease. Our laboratory is interested in examining the effects of prenatal insults on the ontogeny of xenobiotic metabolism and pharmacokinetics of drugs in the offspring. Specifically, we are interested in determining if transient insults during susceptible periods in fetal development can program alterations in drug metabolism and pharmacokinetics which are long term, and possibly permanent. Understanding the molecular mechanisms responsible for such alterations is an important aspect of the research program in our laboratory.
Publications
Ruchi Shah and Anil D'mello. Stabilization of phenyalanine ammonia lyase against organic solvend medicated deactiviation. Int. J. Pharmaceutics under review
Genesh Cherala, Bernard H. Shapiro and Anil P. D'mello. Differences in the effects of two low protein diets on food consumption and reproductive performance in pregnant and lactating rats and on long term growth of their offspring. J. Nutrition. Provisionally Accepted, 2006
Anil P. D'mello and Ying Liu. Effects of maternal immobilization stress on birth weight and glucose homeostasis in the offspring. Psychoneuroendocrinology 31, 395-406 (2006).
William J. Cassano Jr. and Anil P. D'mello. Acute stress induced facilitation of the hypothalamic- pituitary- adrenal axis: Role of stressor duration and serotonin. Neuroendocrinology 74, 167-177, (2001)
Susan Habibi-Moini, and Anil P. D'mello. Evaluation of possible reasons for the low phenylalanine ammonia lyase activity within cellulose nitrate membrane microcapsules. Int. J. Pharmaceutics., 215:185-196 (2001).
Y. Nancy Wong, William J. Cassano Jr., and Anil P. D'mello, Acute Stress induced facilitation of the hypothalamic- pituitary- adrenal axis. Neuroendocrinology, 71:354-365 (2000).