Murray Zanger (Emeritus), PhD
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Murray Zanger (Emeritus)
Professor
Ph.D., Organic Chemistry
University of Kansas, 1959
Organic Chemistry
Chemical Education
Medicinal Chemistry
Pharmaceutical Chemistry
GH 326
215.596.8838
m.zanger@usp.edu
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Research Interests
- Organic syntheses
- Medicinal chemistry
- Proton NMR
Research Summary
My research has uncovered a class of compounds with significant anti-AIDS activity. Using medicinal chemical principles I am trying to design and synthesize more active members in this family. One example of these novel drugs, NCI-667951, or 2-(2-nitrophenylsulfonyl)-N, 4-dimethylaniline, is shown. Other research involves the large-scale synthesis of a key intermediate of adriamycin, a naturally occurring anti-cancer agent.
However, it should be noted that as a result of my recent appointment as an Emeritus Professor, effective in Fall 2002, I will not be accepting any new research students into my laboratory. I will continue to direct the graduate students currently working in my laboratory, and will continue to be available for consultation in my areas of expertise.
Recent or Representative Publications
“Synthesis of Tetrahydrobenzazepinesulfonamides and Their Rearrangement to Diarylsulfones,” H. Ren, M. Zanger, and J. McKee, Syn. Comm., 2006, 36, 355.
“Measurement of the Isotopic Ratio of 10B/11B in NaBH4 by 1H NMR,” M. Zanger and G. Moyna, J. Chem. Ed., 2005, 82, 1390.
“Synthesis of Anthracyclinone Precurosr: 5, 12-Dihydroxy-1,3,4- Trihydronaphthacene-2,6,11-Quinone,” G. Trirya and M. Zanger, Syn. Comm., 2004, 34, 3047.
“The Electrophilic Bromation of Toluene: Determination of the ortho, meta and para Ratios by Quantitative FTIR Spectrometry,” R. Smith IV, J. McKee, and M. Zanger, J. Chem. Ed., 2002, 79, 227.
“A Microscale Synthesis of 2,3-Dibromosuccinic Acid,” J. Tomsho, M. Zanger and J. McKee, J. Chem Ed., 1999, 76, 73.
“A Diarylsulfone Nonnucleoside Reverse Transcriptase Inhibitor with a Unique Sensitivity Profile to Drug-Resistant Virus Isolates,” R. W. Buckheit, V. Fliakas-Boltz, J. D. Russell, M. Snow, S. S. Yang, J. P. Bader, T. N. Khan, and M. Zanger, Antiviral Chemistry & Chemotherapy, 1996, 7(5), 243.
“The Aromatic Substitution Game,” M. Zanger, A. R. Gennaro, and J. R. McKee, J. Chem. Ed., 1993, 70, 985