Yumee K. Koo, PhD
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Yumee K. Koo
Assistant Professor
Ph.D., Biochemistry
University of Illinois, Chicago, 1997
Biochemistry
Chemical Education
Organic Chemistry
Griffith Hall 142
215.596.7546
y.koo@usp.edu
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Research Interests
- Chemical education
- Protein interactions
Research Summary
I am interested in the study of the mechanisms of macromolecular interactions, including protein-lipid and protein-inhibitor interactions. Efforts are focused on the characterization of proteins using biochemical and spectrometric techniques, and the development of kinetic and binding assays for therapeutically important enzymes.
Recent or Representative Publications
Liu, YM.; Chen, FQ.; Putt, M.; Koo, YK.; Madaio, M.; Cambier, JC.; Cohen, PL.; Eisenberg, RA “ B cell Depletion with anti-CD79 mabs ameliorates autoimmune disease in MRL\ LPR mice”.; J. of Immunology , 2008, 181, 2961- 2972.
“Purification and Inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenasefrom Beef Liver,” Dhirendra Nandi, Eric S. Lightcap, Yumee K. Koo,Xingliang Lu, Jean Quancard, and Richard B.Silverman, Int. J. Biochem. Cell Biol., 2003, 35(7),1085.
“Multiple Active Enzyme Species of gamma-aminobutyric acid aminotransferase Are Not Isozymes,” Yumee Kim Koo, Dhirendra Nandi, and Richard B. Silverman, Arch. Biochem. Biophys., 2000, 374, 248.
“Structure Based Design: Novel Spirocyclic Ethers as Nonpeptidal P2-Ligands for HIV Protease Inhibitors,” Arun K. Ghosh, Wonhwa Cho, Yumee Kim Koo, et al., Bioorg. Med. Chem. Lett., 1998, 8, 979.
“Potent HIV Protease Inhibitors Incorporating High-Affinity P2-Ligands and (R)-(Hydroxyethylamino) sulfonamide Isostere,” Arun K. Ghosh, Wonhwa Cho, Yumee Kim Koo, et al., Bioorg. Med. Chem. Lett., 1998, 8, 687.
“A Phospholipase A2 Kinetic and Binding Assay Using Phospholipid-Coated Hydrophobic Beads,” Yumee Kim, Lenka Lichtenbergova, Yana Snitko, and Wonhwa Cho, Analytical Biochemistry, 1997, 250, 109.