University of the Sciences in Philadelphia

Suzanne K. Murphy, Ph.D. Professor of Biology Director of Pre-Health Professions Programs Dean of Misher College of Arts and Sciences Contact Info: Office: GH 212C Griffith Hall Building Voice: 215.596.8921 Fax: 215.596.8764 Email: s.murphy@usciences.edu

Training and Degrees

Post-Doctoral Fellowship, Albert Einstein Medical Center Department of Pediatrics Philadelphia, PA 1984-1985
Post-Doctoral Fellowship, SmithKline and French Laboratories Corp.Department of Tumor Biology Philadelphia, PA 1983-1984
Ph.D. Hahnemann University School of Medicine Philadelphia, PA 1983
B.A. Rosemont College, Rosemont, PA 1977

Prior Positions

Associate Dean, Misher College of Arts and Sciences
Director of Undergraduate Programs, Dept. of Biological Sciences

Memberships in Professional Organizations

American Society for Cell Biology
American Association for the Advancement of Science
Sigma Xi
National Association of Advisors for the Health Professions
(member Board of Directors 2000-2002, Secretary 2002-present)
Northeast Association of Advisors for the Health Professions
(member of Executive Board 1996-2000, President 2000-2001)
Association for Women in Science
Association for Women in Cancer Research

Research Interests

Analysis of expression of the ras oncogene in NIH3T3 fibroblasts.
Alterations in signal transduction pathways and expression of heat shock proteins.
Association between osmotic stress and heat shock protein expression.

Selected Recent Publications

(* indicates undergraduate student)
(** indicates graduate student)

P. Patel, H. Tyagi, A. Khanna, M. Kasschau and S. Murphy. “Role of P38MAPK and heat shock proteins, HSP27 and HSP70, in Osmotic Stress in Renal vs. Blood Cells: A Comparative Study.” Molecular Biology of the Cell,19, 0361 (2008).

P. Patel, M. Dutt, M.R. Kasschau and S.K. Murphy. “Effect of P38MAPK on Filopodial Formation in KGla Human Hemotopoietic Cell Line.” Molecular Biology of the Cell, 18, 169 (2007).

Formation in a Human Hematopoietic Cell Line under Hypertonic Stress.” Molecular Biology of the Cell, 17, 2361 (2006)

A. Khanna, M.R. Kasschau and S.K. Murphy. “Cytoskeletal Reorganization in a Kidney Cell Line (LLC-PK1) under Hypertonic Stress.” Molecular Biology of the Cell, 17, 2361 (2006).

P. Patel, H. Tyagi, A. Khanna, M. Kasschau and S. Murphy. “Role of P38MAPK and heat shock proteins, HSP27 and HSP70, in Osmotic Stress in Renal vs. Blood Cells: A Comparative Study.” Molecular Biology of the Cell (2008).

M.D. Dutt, M.R. Kasschau and S.K. Murphy. “Filopodia formation in the KG1a human hematopoietic cell lineand earthworm coelomocytes under hypertonic osmotic stress.”Molecular Biology of the Cell, submitted (2005).

C. E. O’Brien and S.K. Murphy. “Interaction between PKC and HSP 70 in Fibroblasts overexpressing cellular Ras.” Molecular Biology of the Cell, submitted (2005).

C. O’Brien*, D. Lakic* and S.K. Murphy. “HSP70 levels are elevated in fibroblasts overexpressing cellular Ras protein.” Molecular Biology of the Cell, 15:361a (2004).

M. Braun*, W. Ding* and S.K. Murphy. “Regulatory interactions of PIP2-PLC, PC-PLD and PKC in cultured mouse fibroblasts.” Molecular Biology of the Cell, 14:147a (2003).

S.K. Murphy, R. Kareem*, Y.Lai* and J. Worobiej*. “Effects of overexpression of cellular ras vs. mutated ras.” Molecular Biology of the Cell 11:242a (2000).

W.Ding*, Y. Kwok* and S.K. Murphy. “Reciprocal regulations of PI-PLC and PC-PLC/PLD in ras transformed fibroblasts.” Molecular Biology of the Cell 9:117a (1998).

S.A. Morine*, S.K. Murphy and M.R. Kasschau. Cytoskeletal changes in coelomocytes from the earthworm, Lumbricus Terrestris, stimulated to adhere to immobilized protein matrices. Molecular Biology of the Cell, 8:270a, (1997).

T.T. Ho*, T.M. Allen* and S.K. Murphy. Ras p21 regulates phospholipase D through the cAMP cascade. Molecular Biology of the Cell, 8:142a, (1997).

T. Ho* and S.K. Murphy. Regulation of phospholipase C and D by RAS p21 and Protein kinase C. Molecular Biology of the Cell, 7:343a (1996).

S.K. Murphy, S. Robb-Gaspers* and A.M. Haines*. Protein kinase C regulates the activity of phospholipase C and phospholipase D in ras-expressing and non-ras-expressing NIH3T3 cells. Proceedings of the American Association for Cancer Research, 36:53 (1995).