William R. Law, PhD
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William R. Law, Ph.D.
Professor of Biology
Vice Dean of Misher College of Arts and Sciences
Director, Forensic Science Program
Contact Info:
Office: Griffith Hall, Room 212C
Voice: 215.596.7443
Fax: 215.596.8764
Email: w.law@usciences.edu
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Training and Degrees
Post-Doctoral training: Loyola University Medical Center, 1986-1988
Ph.D. University of Illinois College of Medicine at Chicago 1985
B.A. Augustana College, Rock Island, IL 1979
B.A. Central High for Boys, Philadelphia, PA 1974
Prior Positions
Associate Professor of Physiology: University of Illinois at Chicago, Chicago, IL 1991-2005
Senior Scientist I: Geo-Centers, Inc. under contract to Naval Medical Research Institute, Bethesda, MD. 1989-1991
Assistant Professor, Department of Surgery, Loyola University Medical Center, Maywood, IL 1988-1989
Instructor, Barat College, Lake Forest, IL 1987-1989
Visiting Professor, Gama Filho University, Rio de Janeiro, R.J., Brasil 1985-1986
High School Teacher (basic and advanced physics) Alleman High School, Rock Island, IL 1979-1981
Membership in Professional Organizations
American Physiological Society (Full)
American Heart Association
American Diabetes Association (Professional)
International Society for Heart Research (Full)
Shock Society
Society for Critical Care Medicine (Full)
Research Interests
Our laboratory is exploring the role of extracellular purine metabolism in the regulation of purine autocrine and paracrine signaling. Special emphasis is focused on the central position of bound and unbound adenosine deaminase in this process. These studies have far-reaching physiological significance, and are pivotal in the clinical manifestations associated with sepsis and the systemic inflammatory response syndrome (SIRS).
Selected Recent Publications
LAW, W.R., Conlon, B.A., and Ross, J.D. The Extracellular Cardiac Purine Metabolome in Sepsis. Shock. 28(3):259_264, 2007
Ross JD, Ripper R, Law WR, Massad M, Murphy P, Edelman L, Conlon BA, Feinstein DL, Palmer JW, DiGregorio G, Weinberg GL. Adding bupivacaine to high_K cardioplegia improves function and reduces cellular damage of rat isolated hearts after prolonged, cold storage. Anesthesiology, 105(4):746_52, 2006.
LAW, W.R. Adenosine receptors in the response to sepsis: What do receptor-specific knockouts tell us? American Journal of Physiology: Regulatory, Integrative, and Developmental Physiology. 291(4):R957-8, 2006
LAW, W.R. Transgenic approaches to reintegration: Adenosine deaminase deficiency improves ischemic tolerance. Cardiovascular Research. 71: 8-9, 2006
Conlon, B.A., Ross, J.D., and LAW, W.R. Advances in understanding adenosine as a plurisystem modulator in sepsis and the systemic inflammatory response syndrome (SIRS). Frontiers in Bioscience 10:2548_65, 2005
LAW, W.R., Ross, J.D., and Jonjev, Z.S. Adenosine attenuates C-terminal but not N-terminal proteolysis of cTnI during cardioplegic arrest. J. Surg. Res. 123:126_33, 2005